The highly anticipated anime adaptation of My Friend’s Little Sister Has It In for Me has revealed its first teaser visual and trailer, marking the long-awaited return of the series after a four-year wait since its initial announcement. The October 2025 premiere is set to bring this comedic romance anime to life, and fans are excited about the new updates shared at GA Fes 2025.
Studio BLADE Brings the Series to Life
Studio BLADE will animate the anime series, with Kazuomi Koga as the director, Toko Machida handling the scriptwriting, and Katsuyuki Sato as the character designer. The series was first announced at GA Fes 2021, with updates gradually released over the years, including major news at GA Fes 2024. The trailer dropped today at GA Fes 2025, and it has quickly captured the attention of fans eager for more information on the show.
Returning Voice Cast: Fan Favorites Reprise Their Roles
The voice cast from the original drama CD adaptation is set to return for the anime, including:
- Haruki Ishiya as Akiteru Ooboshi
- Sayumi Suzushiro as Iroha Kohinata
- Tomori Kusunoki as Mashiro Tsukinomori
- Spma Saitp as Ozuma Kohinata
- Kana Hanazawa as Sumire Kageishi
These talented voice actors will bring their beloved characters back to life in this romantic comedy anime filled with humor and heart.
The Story: A Comedic Tale of Teasing and Romance
My Friend’s Little Sister Has It In for Me follows the story of Akiteru Ooboshi, a young man who has never had much luck with women. Despite his best efforts, every girl he interacts with treats him with disdain, leaving him frustrated and confused about relationships. His luck takes a turn when his uncle demands that Akiteru pretend to be his daughter’s boyfriend in order to secure a spot at his uncle’s game development company.
However, the real challenge arises from Iroha Kohinata, the best friend’s little sister and a relentless bully who has no shortage of teasing and scorn for Akiteru. Will this fake relationship turn into something real? Fans can expect a mix of comedy, romance, and slice-of-life moments as Akiteru navigates his awkward, often hilarious interactions with Iroha.
Source Material: Light Novels and Manga Adaptations
The anime is based on the light novel series by Mikawa Ghost, with illustrations by Tomari. The series began in April 2019 and has since been compiled into 10 volumes as of late 2024. In addition to the light novel, there’s a manga adaptation illustrated by Hira Hiraoka, serialized in Square Enix’s Manga Up! magazine. The manga is also available in English via Comikey, while J-Novel Club publishes the light novel in English.
What to Expect from the Anime
With the October 2025 premiere on the horizon, anime fans are eagerly anticipating the romantic comedy and slice-of-life elements that made the light novels and manga so popular. If you’re a fan of romantic comedies, harem anime, or teasing relationship dynamics, this series is sure to keep you entertained with its humorous yet heartfelt storyline.
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